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In our batch-handling workflow, pre-measured delivery has two practical consequences for reproducibility: dose-to-dose variance is constrained by the device mechanism rather than by pipetting technique, and inter-operator drift across a multi-week study window is meaningfully reduced

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Reduced SAM concentrations, as a consequence of low methionine intake or folate deficiency, mainly lead to a deregulation in DNA methylation and are implicated in various cancers, including colorectal cancer ( Reference Kim 5 , Reference Giovannucci, Rimm and Ascherio 6 )